It explores Cesena’s efforts to achieve climate neutrality and resilience through the sustainable management of the Savio River. Historically intertwined with the river’s ecosystem, the city faces challenges such as flooding – exemplified by a major 2023 event -while striving to balance hydraulic safety, biodiversity, and urban development. Using the NEB Impact Model, the chapter assesses stakeholder dynamics and local sustainability practices across key dimensions: climate resilience, water and land use, open space quality, and civic participation. While Cesena has made progress in environmental and socio-cultural governance, gaps persist in circular economy integration, cultural sustainability, and legal-economic frameworks. The analysis underscores the need for a participatory, nature-based solutions approach to strengthen multi-stakeholder collaboration and community empowerment. By addressing these challenges, Cesena can advance its vision of a climate-neutral river-city, ensuring long-term ecological and socio-economic resilience.